The deregulated microRNAome contributes to the cellular response to aneuploidy.

ABSTRACT:

Background

Aneuploidy, or abnormal chromosome numbers, severely alters cell physiology and is widespread in cancers and other pathologies. Using model cell lines engineered to carry one or more extra chromosomes, it has been demonstrated that aneuploidy per se impairs proliferation, leads to proteotoxic as well as replication stress and triggers conserved transcriptome and proteome changes.

Results

In this study, we analysed for the first time miRNAs and demonstrate that their expression is altered in response to chromosome gain. The miRNA deregulation is independent of the identity of the extra chromosome and specific to individual cell lines. By cross-omics analysis we demonstrate that although the deregulated miRNAs differ among individual aneuploid cell lines, their know

SUBMITTER: Durrbaum M 

PROVIDER: S-EPMC6389165 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature