Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions.

ABSTRACT: Microtubule-associated protein tau aggregates constitute the characteristic neuropathological features of several neurodegenerative diseases grouped under the name of tauopathies. It is now clear that the process of tau aggregation is associated with neurodegeneration. Several transgenic tau mouse models have been developed where tau progressively aggregates, causing neuronal death. Previously we have shown that transplantation of astrocytes in P301S tau transgenic mice rescues cortical neuron death, implying that the endogenous astrocytes are deficient in survival support. We now show that the gliosis markers Glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100β) are elevated in brains from P301S tau mice compared to control C57Bl/6 mice whereas the expression o

SUBMITTER: Sidoryk-Wegrzynowicz M 

PROVIDER: S-EPMC6389177 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature