Nanoscale click-reactive scaffolds from peptide self-assembly.

ABSTRACT:

Background

Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as this self-assembly results in extremely strong, stable quasi-one-dimensional structures which can be used to organise a wide range of cargo species including proteins and oligonucleotides. However, assembly of peptides already conjugated to proteins is limited to cargo species that do not interfere sterically with the assembly process or misfold under the harsh conditions often used for assembly. Therefore, a general method is needed to conjugate proteins and other molecules to amyloid fibrils after the fibrils have self-assembled.

Results

Here we have d

SUBMITTER: Guttenplan APM 

PROVIDER: S-EPMC6389178 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature