Characterization of hepatitis B and delta coinfection in Israel.

ABSTRACT:

Background

Characteristics of hepatitis B (HBV) and delta (HDV) coinfection in various geographical regions, including Israel, remain unclear. Here we studied HDV seroprevalence in Israel, assessed HDV/HBV viral loads, circulating genotypes and hepatitis delta antigen (HDAg) conservation.

Methods

Serological anti HDV IgG results from 8969 HBsAg positive individuals tested in 2010-2015 were retrospectively analyzed to determine HDV seroprevalence. In a cohort of HBV/HDV coinfected (n=58) and HBV monoinfected (n=27) patients, quantitative real-time PCR (qRT-PCR) and sequencing were performed to determine viral loads, genotypes and hepatitis delta antigen (HDAg) protein sequence.

Results

6.5% (587/8969) of the HBsAg positive patients were positive for anti HDV antibodies

SUBMITTER: Shirazi R 

PROVIDER: S-EPMC6389180 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature