Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice.

ABSTRACT:

Background

Angiotensin II (Ang II), a peptide hormone involved in the development of hypertension, causes systemic and cerebral inflammation, affecting brain regions important for blood pressure control. The cause-and-effect relationship between hypertension and inflammation is two-way, but the role of blood pressure in the induction of cerebral inflammation is less clear. The vulnerability of specific brain regions, particularly those important for memory, is also of interest.

Methods

We used molecular biology approaches, immunohistochemistry, and electron microscopy to examine the interdependence between the hypertensive and pro-inflammatory effects of Ang II. We examined the effect of blood pressure by administering a subpressive (200 ng/kg/min) or a pressive Ang II dose

SUBMITTER: Iulita MF 

PROVIDER: S-EPMC6389185 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature