Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia.

ABSTRACT:

Background

The human intestine and its microbiota is the most common infection site for soil-transmitted helminths (STHs), which affect the well-being of ~ 1.5 billion people worldwide. The complex cross-kingdom interactions are not well understood.

Results

A cross-sectional analysis identified conserved microbial signatures positively or negatively associated with STH infections across Liberia and Indonesia, and longitudinal samples analysis from a double-blind randomized trial showed that the gut microbiota responds to deworming but does not transition closer to the uninfected state. The microbiomes of individuals able to self-clear the infection had more alike microbiome assemblages compared to individuals who remained infected. One bacterial taxon (Lachnospiracae) was ne

SUBMITTER: Rosa BA 

PROVIDER: S-EPMC6389212 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature