MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes.

ABSTRACT:

Background

Diabetes mellitus is characterized by chronic vascular disorder and presents a main risk factor for cardiovascular mortality. In particular, hyperglycaemia and inflammatory cytokines induce vascular circulating tissue factor (TF) that promotes pro-thrombotic conditions in diabetes. It has recently become evident that alterations of the post-transcriptional regulation of TF via specific microRNA(miR)s, such as miR-126, contribute to the pathogenesis of diabetes and its complications. The endothelial miR-19a is involved in vascular homeostasis and atheroprotection. However, its role in diabetes-related thrombogenicity is unknown. Understanding miR-networks regulating procoagulability in diabetes may help to develop new treatment options preventing vascular complications.

SUBMITTER: Witkowski M 

PROVIDER: S-EPMC6389222 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature