Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naive pigs and the quasi-species variation of the virus during infection in vaccinated pigs.

ABSTRACT: This paper describes the results of two experiments regarding porcine reproductive and respiratory syndrome virus (PRRSV1): the first one studied the existence of bottlenecks in an experimental one-to-one model of transmission in pigs; while the second analysed the differences between viral quasi-species in vaccinated pigs that developed shorter or longer viraemias after natural challenge. Serum samples, as well as the initial inoculum, were deep-sequenced and a viral quasi-species was constructed per sample. For the first experiment, the results consistently reported a reduction in the quasi-species diversity after a transmission event, pointing to the existence of bottlenecks during PRRSV1 transmission. However, despite the identified preferred and un-preferred transmitted variants not b

SUBMITTER: Cortey M 

PROVIDER: S-EPMC6389235 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature