HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses.

ABSTRACT:

Background

Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response to denervation, suggesting the use of HDAC inhibitors as a therapeutic approach to neurogenic muscle atrophy. However, the effects of HDAC4 inhibition in skeletal muscle in response to long-term denervation have not been described yet.

Methods

To further study HDAC4 functions in response to denervation, we analyzed mutant mice in which HDAC4 is specifically deleted in skeletal muscle.

Results

After an initial phase of resistance to neurogenic muscle atrophy, skeletal muscle with a deletion of HDAC4 lost structural integ

SUBMITTER: Pigna E 

PROVIDER: S-EPMC6389241 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature