The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors.

ABSTRACT:

Background

The insulin receptor (INSR) and the insulin growth factor 1 receptor (IGF1R) play important roles in the etiology of both diabetes mellitus and breast cancer. We aimed to evaluate the expression of hormone and insulin-related proteins within or related to the PI3K and MAPK pathway in breast tumors of women with or without diabetes mellitus, treated with or without insulin (analogues).

Methods

Immunohistochemistry was performed on tumor tissue of 312 women with invasive breast cancer, with or without pre-existing diabetes mellitus, diagnosed in 2000-2010, who were randomly selected from a Danish breast cancer cohort. Women with diabetes were 2:1 frequency matched by year of birth and age at breast cancer diagnosis to those without diabetes. Tumor Microarrays were s

SUBMITTER: Bronsveld HK 

PROVIDER: S-EPMC6389252 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature