Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells.

ABSTRACT: Both renin-angiotensin systems and insulin participate in kidney-involved blood pressure regulation. Activation of angiotensin II type 2 receptor (AT₂R) decreases sodium reabsorption in renal proximal tubule (RPT) cells, whereas insulin produces the opposite effect. We presume that AT₂R has an inhibitory effect on insulin receptor expression in RPT cells, which may affect renal sodium transport and therefore be of physiological or pathological significance. Our present study found that activation of AT₂R inhibited insulin receptor expression in a concentration and time-dependent manner in RPT cells from Wistar-Kyoto (WKY) rats. In the presence of a protein kinase C (PKC) inhibitor (PKC inhibitor peptide 19-31, 10^-6 mol/L) or a phosphatidylinosito

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6389274 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature