SLiM 3: Forward Genetic Simulations Beyond the Wright-Fisher Model.

ABSTRACT: With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology. The SLiM forward genetic simulation framework is one of the most powerful and widely used tools in this area. However, its foundation in the Wright-Fisher model has been found to pose an obstacle to implementing many types of models; it is difficult to adapt the Wright-Fisher model, with its many assumptions, to modeling ecologically realistic scenarios such as explicit space, overlapping generations, individual variation in reproduction, density-dependent population regulation, individual variation in dispersal or migration, local extinction and recolonization, mating between subpopulations, age

SUBMITTER: Haller BC 

PROVIDER: S-EPMC6389312 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature