Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.

ABSTRACT: Pleiotropy is the well-established idea that a single mutation affects multiple phenotypes. If a mutation has opposite effects on fitness when expressed in different contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce the efficacy of selection by limiting the fixation of beneficial mutations through adaptation, and the removal of deleterious mutations through purifying selection. Although this has been widely discussed, in particular in the context of a putative "gender load," it has yet to be systematically quantified. In this work, we empirically estimate to which extent different pleiotropic regimes impede the efficacy of selection in Drosophila melanogaster. We use whole-genome polymorphism data from a single African population and divergence data from D.

SUBMITTER: Fraisse C 

PROVIDER: S-EPMC6389323 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature