The influence of age-associated comorbidities on responses to combination antiretroviral therapy in older people living with HIV.

ABSTRACT:

Introduction

Multiple comorbidities among HIV-positive individuals may increase the potential for polypharmacy causing drug-to-drug interactions and older individuals with comorbidities, particularly those with cognitive impairment, may have difficulty in adhering to complex medications. However, the effects of age-associated comorbidities on the treatment outcomes of combination antiretroviral therapy (cART) are not well known. In this study, we investigated the effects of age-associated comorbidities on therapeutic outcomes of cART in HIV-positive adults in Asian countries.

Methods

Patients enrolled in the TREAT Asia HIV Observational Database cohort and on cART for more than six months were analysed. Comorbidities included hypertension, diabetes, dyslipidaemia and impaire

SUBMITTER: Ahn MY 

PROVIDER: S-EPMC6389354 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature