Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.

ABSTRACT: Background and Purpose- Previously, murine models Krit1 ^+/- Msh2 ^-/- and Ccm2 ^+/- Trp53 ^-/- showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock). Herein, we concurrently investigated treatment of the more aggressive Pdcd10/Ccm3 model with fasudil, simvastatin, and higher dose atorvastatin to determined effectiveness of Rock inhibition. Methods- The murine models, Pdcd10 ^+/- Trp53 ^-/- and Pdcd10 ^+/- Msh2 ^-/-, were contemporaneously t

SUBMITTER: Shenkar R 

PROVIDER: S-EPMC6389370 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature