Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.

ABSTRACT: OBJECTIVE:Whereas the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are nonexistent. This study assessed genetic contributions to spontaneous adiposity in this species. METHODS:Phenotypic variation by age class and sex for BMI, waist to height ratio, waist to thigh ratio, and waist circumference was assessed in 583 macaques. Total and sex-specific heritability for all traits was estimated, including waist to thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. In addition, functional genetic variation at BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and SIM1 was assessed in four animals with extreme spontaneous adiposity. RESULTS:Trait heritability in the combined sample was low to moderate

SUBMITTER: Raboin MJ 

PROVIDER: S-EPMC6389383 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature