The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women.

ABSTRACT:

Objective

The alpha2C adrenoreceptor deletion 322-325 (ADRA2C del 322-325) polymorphism has been associated with autonomic activity and thermoregulation, which are implicated in the vasomotor symptom (VMS) mechanism. The ADRA2C del (322-325) has higher prevalence in African American women, a group known to experience more frequent and bothersome VMS. We assessed whether the ADRA2C del (322-325) genotype is associated with increased frequency of VMS in African American women.

Methods

DNA samples from African American (N = 400) women participating in the Study of Women's Health Across the Nation (SWAN) were genotyped for the ADRA2C del (322-325) polymorphism. Longitudinal data on VMS were obtained from the SWAN repository. The relation of ADRA2C del (322-325) genotypes (deleti

SUBMITTER: Aharon DA 

PROVIDER: S-EPMC6389394 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature