The gut microbiome in food allergy.

ABSTRACT:

Objective

To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field.

Data sources

A review of the published literature was performed with PubMed, and clinical studies catalogued at ClinicalTrials.gov were also reviewed.

Study selections

The most recent relevant studies, seminal works, and topical clinical trials were selected.

Results

Gut dysbiosis likely precedes the development of food allergy, and the timing of such dysbiosis is critical. Gut microbiota associated with individual food allergies may be distinct. Murine models support the importance of gut microbiota in shaping immune maturation and tolerance. Gut microbiota ma

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6389411 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature