Diet in the Driving Seat: Natural Diet-Immunity-Microbiome Interactions in Wild Fish.

ABSTRACT: Natural interactions between the diet, microbiome, and immunity are largely unstudied. Here we employ wild three-spined sticklebacks as a model, combining field observations with complementary experimental manipulations of diet designed to mimic seasonal variation in the wild. We clearly demonstrate that season-specific diets are a powerful causal driver of major systemic immunophenotypic variation. This effect occurred largely independently of the bulk composition of the bacterial microbiome (which was also driven by season and diet) and of host condition, demonstrating neither of these, per se, constrain immune allocation in healthy individuals. Nonetheless, through observations in multiple anatomical compartments, differentially exposed to the direct effects of food and immunity,

SUBMITTER: Friberg IM 

PROVIDER: S-EPMC6389695 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature