Partner-specific prediction of RNA-binding residues in proteins: A critical assessment.

ABSTRACT: RNA-protein interactions play essential roles in regulating gene expression. While some RNA-protein interactions are "specific", that is, the RNA-binding proteins preferentially bind to particular RNA sequence or structural motifs, others are "non-RNA specific." Deciphering the protein-RNA recognition code is essential for comprehending the functional implications of these interactions and for developing new therapies for many diseases. Because of the high cost of experimental determination of protein-RNA interfaces, there is a need for computational methods to identify RNA-binding residues in proteins. While most of the existing computational methods for predicting RNA-binding residues in RNA-binding proteins are oblivious to the characteristics of the partner RNA, there is growing intere

SUBMITTER: Jung Y 

PROVIDER: S-EPMC6389706 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature