Abnormal Dynamic Functional Connectivity Associated With Subcortical Networks in Parkinson's Disease: A Temporal Variability Perspective.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disease characterized by dysfunction in distributed functional brain networks. Previous studies have reported abnormal changes in static functional connectivity using resting-state functional magnetic resonance imaging (fMRI). However, the dynamic characteristics of brain networks in PD is still poorly understood. This study aimed to quantify the characteristics of dynamic functional connectivity in PD patients at nodal, intra- and inter-subnetwork levels. Resting-state fMRI data of a total of 42 PD patients and 40 normal controls (NCs) were investigated from the perspective of the temporal variability on the connectivity profiles across sliding windows. The results revealed that PD patients had greater nodal variability in precentral and pos

SUBMITTER: Zhu H 

PROVIDER: S-EPMC6389716 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature