Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.

ABSTRACT:

Introduction

Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.

Methods

Pittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of

SUBMITTER: Su Y 

PROVIDER: S-EPMC6389727 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature