Natalizumab versus fingolimod and dimethyl fumarate in multiple sclerosis treatment.

ABSTRACT:

Objective

To compare 2-year effectiveness and discontinuation of natalizumab (NTZ) versus fingolimod (FTY) and dimethyl fumarate (DMF) in the treatment of multiple sclerosis (MS).

Methods

Patients prescribed NTZ, FTY, or DMF at the Rocky Mountain MS Center at University of Colorado were identified. Clinician-reported data were retrospectively collected. Outcomes include a composite effectiveness measure consisting of new T2 lesion, gadolinium-enhancing lesion, and/or clinical relapse, individual effectiveness outcomes and discontinuation over 2 years. Logistic regression was used for data analysis on patients matched by propensity scores and using ATT doubly robust weighting estimator.

Results

A total of 451, 271, and 342 patients were evaluated on NTZ, FTY, and DMF o

SUBMITTER: Vollmer BL 

PROVIDER: S-EPMC6389745 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature