Periventricular white matter changes in idiopathic intracranial hypertension.

ABSTRACT:

Objective

To evaluate whether increased cerebrospinal fluid (CSF) pressure causes alteration of periventricular white matter (WM) microstructure in patients with idiopathic intracranial hypertension (IIH).

Methods

In a prospective study, patients with refractory chronic headache with and without IIH performed a neuroimaging study including 3T MRI, 3D Phase Contrast MR venography, and diffusion tensor imaging (DTI) of the brain. Whole-brain voxel-wise comparisons of DTI abnormalities of WM were performed using tract-based spatial statistics. A correlation analysis between DTI indices and CSF opening pressure, highest peak, and mean pressure was also performed in patients with IIH.

Results

We enrolled 62 consecutive patients with refractory chronic headaches. Thirty-fiv

SUBMITTER: Sarica A 

PROVIDER: S-EPMC6389746 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature