Identification of Cancer Hallmarks Based on the Gene Co-expression Networks of Seven Cancers.

ABSTRACT: Identifying the hallmarks of cancer is essential for cancer research, and the genes involved in cancer hallmarks are likely to be cancer drivers. However, there is no appropriate method in the current literature for identifying genetic cancer hallmarks, especially considering the interrelationships among the genes. Here, we hypothesized that "dense clusters" (or "communities") in the gene co-expression networks of cancer patients may represent functional units regarding cancer formation and progression, and the communities present in the co-expression networks of multiple types of cancer may be cancer hallmarks. Consequently, we mined the conserved communities in the gene co-expression networks of seven cancers in order to identify candidate hallmarks. Functional annotation of the communit

SUBMITTER: Yu LH 

PROVIDER: S-EPMC6389798 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature