PIRSitePredict for protein functional site prediction using position-specific rules.

ABSTRACT: Methods focused on predicting 'global' annotations for proteins (such as molecular function, biological process and presence of domains or membership in a family) have reached a relatively mature stage. Methods to provide fine-grained 'local' annotation of functional sites (at the level of individual amino acid) are now coming to the forefront, especially in light of the rapid accumulation of genetic variant data. We have developed a computational method and workflow that predicts functional sites within proteins using position-specific conditional template annotation rules (namely PIR Site Rules or PIRSRs for short). Such rules are curated through review of known protein structural and other experimental data by structural biologists and are used to generate high-quality annotations for t

SUBMITTER: Chen C 

PROVIDER: S-EPMC6389862 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature