Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems.

ABSTRACT: Most targeting strategies of anticancer drug delivery systems (DDSs) rely on the surface functionalization of nanocarriers with specific ligands, which trigger the internalization in cancer cells via receptor-mediated endocytosis. The endocytosis implies the entrapment of DDSs in acidic vesicles (endosomes and lysosomes) and their eventual ejection by exocytosis. This process, intrinsic to eukaryotic cells, is one of the main drawbacks of DDSs because it reduces the drug bioavailability in the intracellular environment. The escape of DDSs from the acidic vesicles is, therefore, crucial to enhance the therapeutic performance at low drug dose. To this end, we developed a multifunctionalized DDS that combines high specificity towards cancer cells with endosomal escape capabilities. Doxorubici

SUBMITTER: Fortuni B 

PROVIDER: S-EPMC6389875 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature