Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.

ABSTRACT: Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt ^-/-, Cd38 ^-/-) or its receptor (Oxtr ^-/-) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt ^-/- and Cd38 ^-/-, but not Oxtr ^-/- mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The incr

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC6389896 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature