Biomolecular Interaction, Anti-Cancer and Anti-Angiogenic Properties of Cobalt(III) Schiff Base Complexes.

ABSTRACT: Two cobalt(III) Schiff base complexes, trans-[Co(salen)(DA)₂](ClO₄) (1) and trans-[Co(salophen)(DA)₂](ClO₄) (2) (where salen: N,N'-bis(salicylidene)ethylenediamine, salopen: N,N'-bis(salicylidene)-1,2-phenylenediamine, DA: dodecylamine) were synthesised and characterised using various spectroscopic and analytical techniques. The binding affinity of both the complexes with CT-DNA was explored adopting UV-visible, fluorescence, circular dichroism spectroscopy and cyclic voltammetry techniques. The results revealed that both the complexes interacted with DNA via intercalation as well as notable groove binding. Protein (BSA) binding ability of these complexes was investigated by absorption and emission spectroscopy which indicate that these complexes

SUBMITTER: Ambika S 

PROVIDER: S-EPMC6389928 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature