Dataset Information

MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.

ABSTRACT: Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally, the use of inconsistent promoter constructs in previous studies has added to the confusion. Therefore, it is necessary to demonstrate the genetic function of MAOA uVNTR and its effects on multiple aspects of aggression. Here, we identified three MAOA alleles in Koreans: the predominant 3.5R and 4.5R alleles, as well as the rare 2.5R allele. There was a minor difference in transcriptional efficiency between the 3.5R and 4.5R alleles, with the greatest value for the 2.5R allele, in contrast to existing research. Psychological indices of aggression did not differ among MAOA genotypes. However, our electroencephalogram and electrocardiogram results obtained under aggression-related stimulation revealed oscillatory changes as novel phenotypes that vary with the MAOA genotype. In particular, we observed prominent changes in frontal γ power and heart rate in 4.5R carriers of men. Our findings provide genetic insights into MAOA function and offer a neurobiological basis for various socio-emotional mechanisms in healthy individuals.

SUBMITTER: Im S

PROVIDER: S-EPMC6390082 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.

Im SeungYeong S Jeong Jinju J Jin Gwonhyu G Yeom Jiwoo J Jekal Janghwan J Lee Sang-Im SI Cho Jung Ah JA Lee Sukkyoo S Lee Youngmi Y Kim Dae-Hwan DH Bae Mijeong M Heo Jinhwa J Moon Cheil C Lee Chang-Hun CH

Scientific reports 20190225 1

Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally, the use of inconsistent promoter constructs in previous studies has added to the confusion. Therefore, it is necessary to demonstrate the genetic func ...[more]

PMID: 30804379

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Dataset Information

MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.

Publications

MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.

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