Baseline Prostate-specific Antigen Level in Midlife and Aggressive Prostate Cancer in Black Men.

ABSTRACT:

Background

Prostate-specific antigen (PSA) measurement in midlife predicts long-term prostate cancer (PCa) mortality among white men.

Objective

To determine whether baseline PSA level during midlife predicts risk of aggressive PCa in black men.

Design, setting, and participants

Nested case-control study among black men in the Southern Community Cohort Study recruited between 2002 and 2009. A prospective cohort in the southeastern USA with recruitment from community health centers. A total of 197 incident PCa patients aged 40-64 yr at study entry and 569 controls matched on age, date of blood draw, and site of enrollment. Total PSA was measured in blood collected and stored at enrollment.

Outcome measurements and statistical analysis

Total and aggressive PCa (91

SUBMITTER: Preston MA 

PROVIDER: S-EPMC6390280 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature