Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs.

ABSTRACT:

Background

The prevalence of overweight is increasing in dogs, but the metabolic events related to this condition are still poorly understood. The purpose of the study was to investigate the postprandial response of plasma metabolites using a meal-challenge test and to identify metabolic variations related to spontaneous overweightness in privately owned dogs.

Results

Twenty-eight healthy male intact Labrador Retriever dogs were included, 12 of which were classified as lean (body condition score (BCS) 4-5 on a 9-point scale) and 16 as overweight (BCS 6-8). After an overnight fast (14-17 h), blood samples were collected and dogs were thereafter fed a high-fat meal. Postprandial blood samples were collected hourly four times. Plasma metabolites were identified by nuclear magne

SUBMITTER: Soder J 

PROVIDER: S-EPMC6390349 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature