HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia.

ABSTRACT:

Background

HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling and HIF1A does not show clinical efficiency because of changeable oxygen concentrations in solid tumor areas. The identification of HIF1A targets expressed in both normoxia and hypoxia and of HIF1A/hypoxia signatures might meliorate the prognostic stratification and therapeutic successes in patients with high-risk solid tumors.

Methods

In this study, we conducted a combined analysis of RNA expression and DNA methylation of neuroblastoma cells silenced or unsilenced for HIF1A expression, grown in normoxia and hypoxia conditions.

Results

The analysis of pathways highlights HIF-1 (he

SUBMITTER: Cimmino F 

PROVIDER: S-EPMC6390360 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature