Systems-level analysis of human aging genes shed new light on mechanisms of aging.

ABSTRACT: Although studies over the last decades have firmly connected a number of genes and molecular pathways to aging, the aging process as a whole still remains poorly understood. To gain novel insights into the mechanisms underlying aging, instead of considering aging genes individually, we studied their characteristics at the systems level in the context of biological networks. We calculated a comprehensive set of network characteristics for human aging-related genes from the GenAge database. By comparing them with other functional groups of genes, we identified a robust group of aging-specific network characteristics. To find the structural basis and the molecular mechanisms underlying this aging-related network specificity, we also analyzed protein domain interactions and gene expression pat

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6390412 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature