Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.

ABSTRACT:

Background

Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions regulated by genomic imprinting. With the recent description of wide-spread polymorphic placenta-specific imprinting, the molecular mechanisms leading to this curious polymorphic epigenetic phenomenon is unknown, as is their involvement in pregnancies complications.

Results

Profiling of 35 ubiquitous and 112 placenta-specific imprinted differentially methylated regions (DMRs) using high-density methylation arrays and pyrosequencing revealed isolated aberrant methylation at ubiquitous DMRs as

SUBMITTER: Monteagudo-Sanchez A 

PROVIDER: S-EPMC6390544 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature