Appraising growth differentiation factor 15 as a promising biomarker in digestive system tumors: a meta-analysis.

ABSTRACT:

Background

Previous studies have highlighted cytokine growth differentiation factor 15 (GDF-15) as a potential biomarker for digestive system tumors (DST). This study sought to assess the feasibility of using GDF-15 as a diagnostic and prognostic biomarker in DST.

Methods

Eligible studies from multiple online databases were reviewed. Meta-analyses of diagnostic parameters were carried out using standard statistical methods. Study-specific hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the relationship between GDF-15 levels and clinical prognosis.

Results

We identified 17 eligible studies comprising 3966 patients with DST. The sensitivity, specificity, and area under the curve (AUC) for the discriminative performance

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6390545 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature