The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis.

ABSTRACT:

Background

Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).

Methods

Electronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. The primary outcome was mortality. Random-effect model was used for quantitative synthesis of the adjusted odds ratio (aOR).

Results

We identified 24 trials in our final analysis. Statistical heterogeneity was found between hyperoxia and normoxia groups in patients with mechanical ventilation (I² = 92%, P < 0.01), cardiac arrest(I² = 63%, P = 0.01), traumatic brain injury (I² = 85%

SUBMITTER: Ni YN 

PROVIDER: S-EPMC6390560 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature