Early improvement in severely ill patients with pneumonia treated with ceftobiprole: a retrospective analysis of two major trials.

ABSTRACT:

Background

Patients with pneumonia who are elderly or severely ill are at a particularly high risk of mortality. This post hoc retrospective analysis of data from two Phase III studies evaluated early improvement outcomes in subgroups of high-risk patients with community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP, excluding ventilator-associated pneumonia [VAP]).

Methods

One study included hospitalised CAP patients randomised to ceftobiprole or ceftriaxone ± linezolid treatment. The other study included HAP patients, who were randomised to ceftobiprole or ceftazidime plus linezolid treatment. The primary outcome was rate of early clinical response (Day 3 in CAP and Day 4 in HAP patients). Additional outcome measures included clinical cure at a test-of-cure

SUBMITTER: Scheeren TWL 

PROVIDER: S-EPMC6390565 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature