Computational modelling of energy balance in individuals with Metabolic Syndrome.

ABSTRACT:

Background

A positive energy balance is considered to be the primary cause of the development of obesity-related diseases. Treatment often consists of a combination of reducing energy intake and increasing energy expenditure. Here we use an existing computational modelling framework describing the long-term development of Metabolic Syndrome (MetS) in APOE3L.CETP mice fed a high-fat diet containing cholesterol with a human-like metabolic system. This model was used to analyze energy expenditure and energy balance in a large set of individual model realizations.

Results

We developed and applied a strategy to select specific individual models for a detailed analysis of heterogeneity in energy metabolism. Models were stratified based on energy expenditure. A substantial surplus

SUBMITTER: Rozendaal YJW 

PROVIDER: S-EPMC6390597 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature