Zoledronic acid blocks the interaction between breast cancer cells and regulatory T-cells.

ABSTRACT:

Background

Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits osteoclastogenesis. Emerging evidence suggests that ZA has anti-tumor and anti-metastatic properties for breast cancer cells. In a mouse model of ZA-related osteonecrosis of the jaw, ZA administration was found to suppress regulatory T-cells (Tregs) function. Our previous reports also demonstrated ZA acted as an immune modulator to block Tregs. Manipulation of Tregs represents a new strategy for cancer treatment. However, the relationship among ZA, Tregs, and cancer cells remains unclear. In this study, we investigated the effects of ZA on the interaction of breast cancer cells and Tregs.

Methods

The anti-tumor effect of ZA on triple negative breast cancer cell lines were validated by XTT, wound

SUBMITTER: Liu H 

PROVIDER: S-EPMC6390606 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature