Real world long-term impact of intensive treatment on disease activity, disability and health-related quality of life in rheumatoid arthritis.

ABSTRACT:

Background

The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes in disease activities and outcomes in a 10-year prospective observational cohort study of patients in routine care at one unit.

Methods

The Guy's and St Thomas' RA cohort was established in 2005. It involved most RA patients managed in this hospital. Clinical diagnoses of RA were made by rheumatologists. Patients were seen regularly in routine care. Each visit included measurement of disease activity scores for 28 joints (DAS28), health assessment questionnaire scores (HAQ) and EuroQol scores. Patients received intensive treatments targeting DAS28 remission.

Results

In 1693 RA patients mean DAS28

SUBMITTER: Gullick NJ 

PROVIDER: S-EPMC6390620 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature