In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR₁₂₀) in Aspergillus fumigatus cyp51A, Denmark.

ABSTRACT: We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

SUBMITTER: Hare RK 

PROVIDER: S-EPMC6390761 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature