Impact of liver kinase B1 on p53 and survivin and its correlation with prognosis in gastric cancer.

ABSTRACT:

Background

Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in apoptosis induction. However, the precise impact of LKB1 expression on gastric cancer (GC) progression and its correlation with survivin and p53 in GC have not yet been elucidated.

Purpose

The aim of this study was to explore the significance of LKB1 expression and its correlation with p53 and survivin in GC.

Patients and methods

In this study, LKB1 expression was detected in GC and adjacent paracancerous tissues from 150 patients through immunohistochemical (IHC) staining. The relationship between LKB1 expression and clinical pathological factors in GC was analyzed, alongside its correlation with p53 and survivin expression.

Results

LKB1 expression was reduced in

SUBMITTER: Li W 

PROVIDER: S-EPMC6390856 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature