JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis.

ABSTRACT: Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of molecules associated with one of the major pathways through which many cytokines exert and integrate their function, and as such they are increasingly recognized as playing critical role in the pathogenesis subserving various immune-mediated diseases, including RA, PsA, SpAs, IBD, skin disorders (e.g. alopecia areata, atopic dermatitis), single-gene disorders like interferonopathies, and others. JAKs are the key initiating players of the JAK/STAT pathway. Upon binding of their respective effector molecules (cytokines, IFNs, growth factors and others) to type I and type II receptors, JAKs are activated, and through phosphorylation of themselves and of other molecules (including STATs), they mediate

SUBMITTER: Fragoulis GE 

PROVIDER: S-EPMC6390879 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature