Allergen Extracts for In Vivo Diagnosis and Treatment of Allergy: Is There a Future?

ABSTRACT: Today, in vivo allergy diagnosis and allergen-specific immunotherapy (AIT) are still based on allergen extracts obtained from natural allergen sources. Several studies analyzing the composition of natural allergen extracts have shown severe problems regarding their quality such as the presence of undefined nonallergenic materials, contaminants as well as high variabilities regarding contents and biological activity of individual allergens. Despite the increasing availability of sophisticated analytical technologies, these problems cannot be overcome because they are inherent to allergen sources and methods of extract production. For in vitro allergy diagnosis problems related to natural allergen extracts have been largely overcome by the implementation of recombinant allergen molecules tha

SUBMITTER: Valenta R 

PROVIDER: S-EPMC6390933 | biostudies-literature | 2018 Nov - Dec

REPOSITORIES: biostudies-literature