Angiotensin II Promotes K_V7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90).

ABSTRACT: Voltage-gated K_v7.4 channels have been implicated in vascular smooth muscle cells' activity because they modulate basal arterial contractility, mediate responses to endogenous vasorelaxants, and are downregulated in several arterial beds in different models of hypertension. Angiotensin II (Ang II) is a key player in hypertension that affects the expression of several classes of ion channels. In this study, we evaluated the effects of Ang II on the expression and function of vascular K_v7.4. Western blot and quantitative polymerase chain reaction revealed that in whole rat mesenteric artery, Ang II incubation for 1 to 7 hours decreased K_v7.4 protein expression without reducing transcript levels. Moreover, Ang II decreased XE991 (K_v7)-sensitive curr

SUBMITTER: Barrese V 

PROVIDER: S-EPMC6390948 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature