In vivo measurement of blood clot mechanics from computational fluid dynamics based on intravital microscopy images.

ABSTRACT: Ischemia which leads to heart attacks and strokes is one of the major causes of death in the world. Whether an occlusion occurs or not depends on the ability of a growing thrombus to resist flow forces exerted on its structure. This manuscript provides the first known in vivo measurement of how much stress a clot can withstand, before yielding to the surrounding blood flow. Namely, Lattice-Boltzmann Method flow simulations are performed based on 3D clot geometries, which are estimated from intravital microscopy images of laser-induced injuries in cremaster microvasculature of live mice. In addition to reporting the blood clot yield stresses, we also show that the thrombus "core" does not experience significant deformation, while its "shell" does. This indicates that the shell is more prone

SUBMITTER: Kadri OE 

PROVIDER: S-EPMC6390965 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature