The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.

ABSTRACT:

Background

Chagas disease is still prevalent in rural areas of South America. In endemic areas of Bolivia, school children are screened for the program of Chagas disease eradication of the Ministry of Health, and positive children are treated. Here, we compared the fecal, oral and skin microbiomes of children with or without Chagas disease, and before and after benznidazol treatment of infected children.

Methods

A total of 543 Bolivian children (5-14 years old) were tested for Chagas disease, and 20 positive children were treated with Benznidazole. Fecal samples and oral and skin swabs were obtained before and after treatment, together with samples from a group of 35 uninfected controls. The 16S rRNA genes were sequenced and analyzed using QIIME to determine Alpha diversity

SUBMITTER: Robello C 

PROVIDER: S-EPMC6391005 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature