Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine.

ABSTRACT: The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes that coordinate the transition between those patterns are poorly understood. We investigated whether in regions with a richer palette of motility patterns, the underlying nerve circuits reflect this complexity. Using Ca²⁺ imaging, we determined the location and response fingerprint of large populations of enteric neurons upon focal network stimulation. Complemented by neuronal tracing and volumetric reconstructions of synaptic contacts, this shows that the multifuncti

SUBMITTER: Li Z 

PROVIDER: S-EPMC6391068 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature