Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy.

ABSTRACT:

Background

Awake neurosurgery requires patients to converse and respond to visual or verbal prompts to identify and protect brain tissue supporting essential functions such as language, primary sensory modalities, and motor function. These procedures can be poorly tolerated because of patient anxiety, yet acute anxiolytic medications typically cause sedation and impair cortical function.

Methods

In this study, direct electrical stimulation of the left dorsal anterior cingulum bundle was discovered to reliably evoke positive affect and anxiolysis without sedation in a patient with epilepsy undergoing research testing during standard inpatient intracranial electrode monitoring. These effects were quantified using subjective and objective behavioral measures, and stimulation wa

SUBMITTER: Bijanki KR 

PROVIDER: S-EPMC6391096 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature